This report is an annual overview of activities led and implemented by the Migration Health Division of the International Organization for Migration (IOM) in 2022, in close collaboration with Member States, other United Nations agencies, and partners, to respond to major health needs in the context of human mobility, meet operational challenges and advance understanding of migration health, encourage socioeconomic development through migration, and work towards ensuring respect of the human dignity and well-being of migrants. The report illustrates the growing multi-dimension of migration health activities and partnerships of IOM in 2022, and demonstrates the Organization’s commitment to advancing the health of migrants and their families worldwide across three key areas of focus: 1. Connecting health security and human mobility; 2. Increasing communities’ health resilience; and 3. Strengthening migration health governance.