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Optimal strategies for control of COVID-19: A mathematical perspective

Author/s
Seidu B.
Year
Language
English
Document Type
Article
Source Title
Scientifica
Publisher
Hindawi Limited

Description

A deterministic ordinary differential equation model for SARS-CoV-2 is developed and analysed, taking into account the role of exposed, mildly symptomatic, and severely symptomatic persons in the spread of the disease. It is shown that in the absence of infective immigrants, the model has a locally asymptotically stable disease-free equilibrium whenever the basic reproduction number is below unity. In the absence of immigration of infective persons, the disease can be eradicated whenever R0 < 1. Specifically, if the controls ui, i = 1, 2, 3, 4, are implemented to 100% efficiency, the disease dies away easily. It is shown that border closure (or at least screening) is indispensable in the fight against the spread of SARS-CoV-2. Simulation of optimal control of the model suggests that the most cost-effective strategy to combat SARS-CoV-2 is to reduce contact through use of nose masks and physical distancing. © 2020 Baba Seidu.

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