Migrants and mobile populations are regarded as most at risk populations in relation to Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS), Sexually Transmitted Infections (STIs) and Tuberculosis (TB). Understanding such vulnerabilities is essential for the development of effective and efficient response strategies, as well as the implementation and monitoring and evaluation thereof. The Study on Health Vulnerabilities of Mobile Populations and Affected Communities in Selected Ports in Southern Africa aims to inform policies, strategies and programmes towards responding to the health needs of these vulnerable population groups. Sustainable Development Africa (SusDAf), a Namibian-based social research firm, was commissioned by International Organisation for Migration (IOM) to carry out the study in Walvis Bay. SusDAf employed a mixed-method research approach, combining quantitative and qualitative research methods, which allowed for statistical analysis to be complemented by in-depth data and vice versa.